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The gradual dose escalation frustrates many patients who want rapid results, but rushing this process almost always backfires

A patient told me, People used to be so mean in public. Now, theyve lost weight and society is treating them better

The selective action remains advantageous for lean individuals because it targets fat specifically without promoting water retention or tissue growth that might obscure definition

This is important because patients who dont lose weight on metformin are considered to be more resistant than others (and therefore more difficult to treat)

doi: 10.1080/21505594.2019.1602020 151 WuX.PedersenK.EdlundJ.ErikssonL.strmM.AnderssonA